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Seek urgent medical attention for sudden severe headache, headache with fever or neck stiffness, new neurological symptoms, or headache following head trauma

If HRT is taken as a pill, semaglutide's slowing of gastric motility could theoretically reduce absorption slightly

When to seek urgent care: Severe or persistent nausea and vomiting leading to dehydration contact NHS 111 or your trial team Sudden, severe abdominal pain seek urgent medical attention Signs of a severe allergic reaction (anaphylaxis), including rash, swelling of the face, lips, or throat, or difficulty breathing call 999 immediately Upper right abdominal pain, fever, or jaundice seek medical attention Any new or worsening symptoms following an injection contact your trial team Reporting side effects: Patients and healthcare professionals are encouraged to report suspected adverse reactions via the MHRA Yellow Card Scheme at yellowcard.mhra.gov.uk or via the Yellow Card app

This personalization dramatically reduces unnecessary discomfort and improves medication adherence

Nausea severity does not indicate medication efficacy or safety

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