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A human study demonstrated that both H 2 O 2 levels (increased by 32% and 46%) and CAT activity (increased by 51% and 89%) were elevated in the visceral fat of overweight/obese (BMI 25) and centrally obese (waist-height ratio 0.5) individuals compared to lean subjects, suggesting that catalase in adipose tissue may undergo compensatory upregulation in response to obesity-induced oxidative stress 30

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