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& Savarese, T

3A), among which 317, 567 and 631 DEGs were up-regulated, and 327, 504 and 367 DEGs were down-regulated (Fig

10.2174/0929867329666211221153719 128 MassaadC

Epigenomics 7 , 10511073 (2015)

18 Mutations in epigenetic-modifying enzymes, whether heterozygous or hemizygous, are commonly associated with congenital conditions, such as Rubinstein-Taybi syndrome, linked to mutations in the cyclic adenosine monophosphate-responsive element-binding protein (CREB)-binding protein (CBP) and its paralog, E1A-binding protein (P300), 19 immunodeficiency-centromeric instability-facial anomalies syndrome related to DNMT3B mutations, 20 and Kabuki syndrome due to mutations in lysine methyltransferase 2D (KMT2D)

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