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The more progressed the deficiency is, the more detrimental it may be to an individual with Hashimotos

Notably, we observed that TF can reduce intracellular iron levels in RPE cells, potentially mitigating iron-induced cellular damage

Unfortunately, the study had numerous pitfalls, including protocol deviations during randomization and slow recruitment

[31] Tsuchiya H, Sato M, Miyazaki T, Fujiwara S, Tanigaki S, Ohyama M, et al

The cause is multifactorial: reduced caloric intake, slower gastric emptying, mild dehydration if water intake drops with appetite, and elevated B12 demand during a rapid metabolic shift